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KMID : 1023420150150040424
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Journal of Dental Hygiene Science
2015 Volume.15 No. 4 p.424 ~ p.429
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Analgesic Effects of Triptolide via Peripheral and Central Administration in Rat Model of Inflammatory Orofacial Pain
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Kim Yun-Kyung
Choi Ja-Hyeong
Lee Hyun-Jung
Son Yoo-Jin
Yoon So-Yeong
Lee Jung-Hwa
Lee Min-Kyung
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Abstract
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The aim of this study was to investigate whether peripheral or central administration of triptolide is involved in pain modulation in inflammatory orofacial pain. The inflammatory orofacial pain was induced by the injection of 5% formalin into right vibrissa pad of rats. The pain behavioral response was measured the number of grooming or scratching on the orofacial area for 9 successive 5 minutes intervals. Triptolide was administrated into the identified vibrissa pad (12.5, 25, 50 μg/50 μl) or intracisternal space (0.01, 0.1, 1 μg/10 μl) 10 min before formalin injection. The nociceptive responses were reduced in the 2nd phase (11∼45 minutes), particularly 20, 30 minutes after fomalin injection following administration of triptolide into vibrissa pad (25, 50 μg/50 μl). Intracisternal (1 μg/10 μl) administration of triptolide alleviated the formalin-induced pain behaviors in the 2nd phase, especially 25∼40 minutes after formalin injection. Triptolide could be a promising analgesic agent in the treatment of inflammatory orofacial pain.
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KEYWORD
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Analgesia, Facial pain, Triptolide
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